mental health15 min readSeptember 16, 2024

What is Kratom? Benefits, Risks, and DEA Concerns Explained

Robin Campbell, LMFT, PHD What is Kratom? Benefits, Risks, and DEA Concerns Explained Kratom, derived from the leaves of the Mitragyna speciosa tree, has gained attention for its use as an herbal medicine and dietary supplement, particularly among those…

Maverick

Clinical Editorial Team

    What is Kratom? Benefits, Risks, and DEA Concerns Explained

    Kratom, derived from the leaves of the Mitragyna speciosa tree, has gained attention for its use as an herbal medicine and dietary supplement, particularly among those seeking alternatives to opioid drugs. Kratom products, including kratom powder and other forms, are often marketed for pain relief, anxiety reduction, and even managing opioid use disorder. However, its rising popularity has sparked concern from health authorities like the Drug Enforcement Administration (DEA) and the Food and Drug Administration (FDA), as they warn consumers about the potential risks associated with kratom. Kratom contains psychoactive compounds that interact with the same receptors in the brain as opioids, leading to questions about its safety, potential for abuse, and the long-term health effects on kratom users. With ongoing research into its health effects, kratom regulation remains a critical focus for policymakers and medical professionals alike.

    What is Kratom? Native to Southeast Asia

    Kratom leaves are derived from the Mitragyna speciosa tree native to Southeast Asia and have been traditionally used in countries like Thailand and Malaysia for their stimulant and pain-relieving properties. These leaves can be consumed by chewing, brewing into tea, or using in capsules, and they contain compounds that can have mind-altering effects. Kratom has gained popularity in the West for managing pain, anxiety, and opioid withdrawal. The active compounds in kratom, primarily mitragynine and 7-hydroxymitragynine, bind to the opioid receptors in the brain, producing effects similar to opioids, though generally milder. Kratom can be consumed in various forms, such as capsules, powders, and teas. While some users find it beneficial for certain conditions, kratom use remains controversial due to its potential for addiction, adverse side effects, and lack of FDA approval.

    Kratom Powder Uses

    Kratom has been used for a variety of purposes, both traditionally and in modern contexts. Some of the common uses of kratom include:

    1. 1Pain Relief: One of the primary reasons people use kratom is to manage chronic pain. The alkaloids in kratom interact with opioid receptors, providing analgesic effects, making it popular among those suffering from conditions like arthritis, fibromyalgia, and back pain.
    1. 1Energy and Focus: In smaller doses, kratom can act as a stimulant, helping to boost energy levels and improve focus. It has been used in Southeast Asia by laborers to combat fatigue and improve work performance.
    1. 1Anxiety and Depression: Some users report that kratom helps alleviate symptoms of anxiety and depression, promoting a sense of well-being and relaxation. However, scientific evidence supporting its efficacy for these conditions is limited.
    1. 1Opioid Withdrawal: Kratom is often used by individuals seeking to reduce dependence on opioids. Its effects on opioid receptors can help ease withdrawal symptoms, such as pain, nausea, and anxiety, making it a potential alternative for those undergoing opioid addiction treatment.
    1. 1Improved Sleep: Some users take kratom for its sedative effects in higher doses, which can help with insomnia and improve sleep quality.

    Kratom Types

    Kratom comes in various strains, typically categorized by the color of the leaf veins and the region where it’s grown. Each type of kratom is believed to have different effects, depending on its alkaloid profile. The three main types of kratom are:

    1. 1Red Vein Kratom: Known for its calming and pain-relieving effects, red vein kratom is often used for relaxation, stress relief, and as a sleep aid. It is also commonly used to manage chronic pain and to help with opioid withdrawal symptoms. Some of the popular red strains include Red Bali, Red Maeng Da, and Red Borneo.
    1. 1Green Vein Kratom: Green vein kratom is considered a balanced strain, offering a mix of stimulating and relaxing effects. It is often used to enhance focus and concentration while providing moderate pain relief. Many people use green vein kratom for anxiety and social discomfort, as it can promote a sense of calm without being overly sedative. Common strains include Green Malay, Green Maeng Da, and Green Thai.
    1. 1White Vein Kratom: White vein kratom is typically more energizing and stimulating than the other types. It is often used as a natural energy booster or as a cognitive enhancer to improve focus, motivation, and mood. White vein kratom can be helpful for those dealing with fatigue or low energy levels. Popular strains include White Borneo, White Thai, and White Maeng Da.

    Each of these kratom types can have varying effects depending on the dosage, with lower doses generally being more stimulating and higher doses offering more sedative effects.

    Kratom Street Names

    Kratom is known by various street names, reflecting its informal use and distribution in different communities. Some common street names for kratom include:

    1. 1Ketum
    1. 1Thang
    1. 1Kakuam
    1. 1Biak-Biak
    1. 1Thom
    1. 1Herbal Speedball
    1. 1Ithang

    These street names often emerge from local slang or cultural references, and while they are used in certain circles, the term “kratom” remains the most widely recognized name for the substance.

    Does Kratom Get You High?

    Yes, kratom can produce a “high,” though the effects vary depending on the strain, dosage, and individual tolerance. In lower doses, kratom typically acts as a stimulant, providing increased energy, alertness, and focus, similar to the effects of caffeine. In higher doses, however, it has more sedative and euphoric effects, similar to opioids. These effects can include a sense of relaxation, calm, pain relief, and, in some cases, mild euphoria.

    The “high” that people experience from kratom is generally milder than stronger opioids but can still be significant. However, it is important to note that while kratom can produce these effects, it also carries risks, including potential for addiction, tolerance, and side effects such as nausea, dizziness, and constipation. Its long-term use or high doses can lead to dependence and withdrawal symptoms.

    Efficacy of Kratom

    The efficacy of kratom remains a topic of debate due to limited scientific research and mixed user reports. While many individuals claim kratom is effective for managing pain, boosting energy, alleviating anxiety, and assisting with opioid withdrawal, the clinical evidence to support these claims is limited and largely anecdotal.

    1. 1Pain Management: Some studies suggest kratom’s alkaloids, primarily mitragynine and 7-hydroxymitragynine, may effectively relieve pain by interacting with opioid receptors in the brain. Kratom compounds have been noted for their safety profile and pharmacological behavior, particularly in comparison to opioids, as they may have a reduced potential for causing respiratory depression. This has led many to use kratom as an alternative to prescription opioids, though more research is needed to validate its safety and efficacy in this context.
    1. 1Opioid Withdrawal: Kratom has been widely used as a self-treatment for opioid withdrawal, as its interaction with opioid receptors can reduce symptoms like cravings and discomfort. However, this practice is not medically recommended due to concerns about kratom’s potential for addiction and limited regulatory oversight.
    1. 1Mood Enhancement and Anxiety Relief: Users frequently report that kratom helps relieve anxiety, improve mood, and reduce symptoms of depression. However, these effects are highly variable and not thoroughly studied, so its efficacy in treating mood disorders remains uncertain.
    1. 1Stimulant Effects: At lower doses, kratom is used for its stimulating effects, helping to increase focus, alertness, and energy. Some studies suggest that these effects may be useful, but there is little clinical evidence to back up its use as a safe and effective stimulant.

    How Does Kratom Work on the Body and Brain?

    Kratom affects the body and brain through its two primary active compounds, mitragynine and 7-hydroxymitragynine, which interact with several receptor systems, particularly opioid receptors. Here’s a more detailed breakdown:

    1. 1Opioid Receptors: Both mitragynine and 7-hydroxymitragynine bind to opioid receptors in the brain, specifically the mu-opioid receptors. This interaction results in pain relief, relaxation, and at higher doses, sedation and euphoria. These effects are similar to opioids, though generally milder.
    1. 1Stimulant Effects: At lower doses, kratom primarily interacts with adrenergic receptors, increasing levels of norepinephrine and dopamine, leading to increased energy, alertness, and focus. Users often describe these effects as similar to caffeine.
    1. 1Sedative and Euphoric Effects: In higher doses, kratom switches from being a stimulant to acting more like a sedative, calming the central nervous system, reducing pain, and promoting relaxation. This effect can lead to a sense of euphoria, similar to opioids, but also increases the risk of addiction.
    1. 1Dependence and Withdrawal: With repeated use, kratom can cause physical dependence as the brain becomes reliant on the opioid-like effects. Stopping kratom use after prolonged exposure can result in withdrawal symptoms similar to opioid withdrawal, including anxiety, irritability, muscle aches, and insomnia.

    Kratom Controlled Substance Classification by the Drug Enforcement Administration

    Kratom’s legal status varies. In the United States, it is not federally classified as a controlled substance but is banned in several states like Alabama, Arkansas, and Wisconsin. The DEA once proposed classifying it as a Schedule I drug but withdrew the proposal after public backlash. Internationally, kratom is banned in countries such as Thailand, Malaysia, and Australia, while it remains legal or unregulated in others like Canada and the UK. Its classification is under review due to concerns over safety and abuse potential.

    Onset and Duration

    The onset and duration of kratom’s effects depend on the dose, strain, and individual factors such as metabolism and tolerance:

    Onset:

    • 15 to 30 minutes: Kratom’s effects typically begin within this time frame after ingestion. When taken on an empty stomach, the onset can be quicker, sometimes in as little as 10 minutes.

    Duration:

    • 2 to 5 hours: The effects of kratom usually last between 2 to 5 hours. Lower doses tend to have shorter durations, while higher doses can extend the effects toward the upper end of this range.
    • Peak effects: These are usually felt around 1.5 to 2.5 hours after consumption.

    The duration may vary based on the strain, with red strains typically lasting longer due to their sedative properties, while white and green strains may have shorter, more stimulating effects.

    How Long Does Kratom Stay in Your System?

    Kratom can stay in your system for varying lengths of time depending on factors such as dosage, frequency of use, metabolism, and individual physiology. The primary alkaloid in kratom, mitragynine, has a half-life of about 7 to 9 hours, meaning it takes this amount of time for half of the substance to be eliminated from the body. Given this half-life, kratom can typically stay detectable in your system for 1 to 3 days in occasional users, while frequent or heavy users may have traces of the substance in their system for up to 5 to 7 days. Drug tests do not routinely screen for kratom, but specialized tests can detect its presence in urine, blood, and hair samples.

    How Long is Kratom Detectable?

    The detectability of kratom in the body depends on the type of test, dosage, and frequency of use:

    1. 1Urine: Kratom can be detected in urine for up to 5 to 7 days, especially in frequent or heavy users. Occasional users may have it detectable for 1 to 3 days.
    1. 1Blood: Kratom is typically detectable in blood for 24 hours after use, though this window may be longer for heavy users.
    1. 1Saliva: There is limited research on kratom’s detection in saliva, but it may be detectable for up to 24 hours after ingestion.
    1. 1Hair: Kratom may be detectable in hair for up to 90 days, similar to many other substances, though hair tests for kratom are less common.

    The specific detection windows can vary based on metabolism, dosage, and the type of kratom used.

    Kratom Side Effects and Risks

    Short-Term Side Effects:

    • Nausea
    • Dizziness
    • Dry mouth
    • Constipation
    • Sweating
    • Loss of appetite
    • Increased urination
    • Sedation (at higher doses)
    • Agitation (at lower doses)

    Long-Term Risks:

    • Dependence and addiction
    • Withdrawal symptoms (similar to opioids)
    • Liver damage
    • Weight loss
    • Insomnia
    • Cognitive impairment
    • Depression and anxiety
    • Potential for respiratory issues with high doses

    Kratom use, especially in high doses or over a long period, can lead to serious health concerns and should be used with caution.

    Is Kratom Addictive?

    Yes, kratom can be addictive, especially with regular or high-dose use. Its active compounds, particularly mitragynine and 7-hydroxymitragynine, interact with opioid receptors in the brain, which can lead to dependence and withdrawal symptoms similar to opioids. Prolonged use increases the risk of addiction, making it important to use kratom with caution.

    Can You Overdose on Kratom?

    Yes, it is possible to overdose on kratom, though it is rare. High doses can cause severe side effects such as extreme sedation, confusion, seizures, elevated heart rate, and in some cases, respiratory depression. While kratom overdoses are typically not fatal on their own, combining it with other substances, especially depressants like alcohol or opioids, can significantly increase the risk of life-threatening complications.

    Alcohol Use and Kratom

    Combining alcohol and kratom can be dangerous due to their potentially synergistic effects. Both substances have depressant qualities at higher doses, which can lead to increased sedation, impaired motor coordination, and a heightened risk of respiratory depression. Mixing the two can also amplify side effects like nausea, dizziness, and confusion, making it more likely for someone to experience blackouts, accidents, or overdose. Additionally, using alcohol and kratom together increases the strain on the liver, raising the risk of liver damage or failure. It is generally advised to avoid using them simultaneously due to these significant health risks.

    Kratom and Pregnancy

    Kratom use during pregnancy is not recommended due to potential risks to both the mother and the fetus. Limited research suggests that kratom can lead to withdrawal symptoms in newborns, similar to opioid withdrawal, as well as potential developmental issues. Additionally, kratom may increase the risk of complications such as low birth weight and preterm labor. Pregnant women should avoid using kratom to minimize these risks.

    What Causes Kratom Addiction and Withdrawal Symptoms?

    Kratom addiction is caused by the active compounds, mitragynine and 7-hydroxymitragynine, which bind to opioid receptors in the brain. This interaction can produce euphoric and pain-relieving effects, leading to repeated use. Over time, the brain becomes dependent on these effects, resulting in tolerance, where higher doses are needed to achieve the same results. Regular use can then lead to physical and psychological dependence, with withdrawal symptoms occurring when kratom use is reduced or stopped.

    Treatment Options for Kratom Addiction

    Treatment options for kratom addiction typically involve a combination of approaches:

    1. 1Detoxification: A medically supervised detox helps manage withdrawal symptoms safely.
    1. 1Behavioral Therapy: Cognitive-behavioral therapy (CBT) and other counseling techniques can help address the psychological aspects of addiction.
    1. 1Support Groups: Groups like Narcotics Anonymous (NA) or specialized addiction support groups provide community and peer support.
    1. 1Medication-Assisted Treatment (MAT): In some cases, medications may be prescribed to ease withdrawal symptoms and cravings.

    Does Insurance Cover Treatment?

    Many insurance plans do cover treatment for kratom addiction, as it falls under the broader category of substance use disorders. Coverage typically includes detoxification, behavioral therapy, and rehabilitation services. However, the extent of coverage varies by plan and provider, so it’s important to check with your insurance company to understand the specific benefits and any out-of-pocket costs. Additionally, certain treatment centers may offer sliding scale fees or payment plans for those without insurance.

    Common Insurance Plans for Addiction

    Here’s a list of common insurance plans that typically cover addiction treatment:

    1. 1Medicaid: A government-funded program that offers coverage for addiction treatment, especially for low-income individuals.
    1. 1Medicare: Provides addiction treatment coverage for those 65 and older or with certain disabilities, including detox and counseling services.
    1. 1Blue Cross Blue Shield: Offers various plans that generally include addiction treatment services such as detox, rehab, and therapy.
    1. 1Aetna: Covers a wide range of addiction treatments, including inpatient and outpatient rehab, detox, and behavioral health services.
    1. 1Cigna: Provides comprehensive coverage for addiction treatment, including counseling, detoxification, and inpatient or outpatient care.
    1. 1UnitedHealthcare: Covers addiction treatment, including residential rehab, outpatient care, and behavioral health services.
    1. 1Humana: Offers plans that often include addiction treatment services such as counseling, detox programs, and rehab.
    1. 1Kaiser Permanente: Provides addiction treatment coverage through its integrated health system, offering both mental health and substance abuse services.
    1. 1Anthem: Offers addiction treatment coverage through various plans, including detox, therapy, and rehab services.
    1. 1Health Net: Includes addiction treatment services in its plans, covering inpatient and outpatient rehabilitation and counseling.

    Always check your specific plan for coverage details and any potential out-of-pocket costs.

    Conclusion

    As kratom continues to be promoted as an herbal extract and self-treatment for various ailments, the need for regulation and research is becoming increasingly apparent. While some users report benefits, kratom exposures, particularly in higher doses, have raised red flags due to safety concerns like kratom withdrawal, interactions with other drugs, and contamination risks such as harmful bacteria or heavy metals. Poison centers have reported cases of adverse effects, and ongoing studies aim to better understand the potential health impacts. Whether viewed as a natural alternative or a substance linked to drug abuse, kratom remains under scrutiny by agencies like the FDA and the Centers for Disease Control (CDC) as they work to protect public health from potential harm.

    Seeking Treatment? We Can Help!

    At New Hope Healthcare, as an in-network provider we work with most insurance plans, such as:

    • First Health Network
    • Aetna
    • Humana
    • TriWest VA
    • UMR
    • Oscar
    • Celtic Insurance
    • And More

    If you or a loved one are struggling with mental health challenges or substance abuse, reach out to New Hope Healthcare today. Our team of compassionate professionals is here to support your journey towards lasting well-being. Give us a call at 866-799-0806 or visit SAMHSA for more information.

    Frequently Asked Questions

    What is kratom?

    Kratom is a plant from Southeast Asia used for its stimulant and opioid-like effects.

    Is kratom legal?

    Kratom is legal in some places but banned in certain U.S. states and countries.

    What is kratom used for?

    Kratom is used for pain relief, energy, and managing opioid withdrawal.

    Can kratom be addictive?

    Yes, regular use can lead to dependence and addiction.

    What are kratom’s side effects?

    Side effects include nausea, dizziness, constipation, and potential liver damage.

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