Amphetamine vs. Dextroamphetamine: Uses, Differences, Side Effects, and More

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Amphetamine and dextroamphetamine are stimulant drugs that are often prescribed for the treatment of attention deficit hyperactivity disorder (ADHD). ADHD is one of childhood’s most common neurodevelopmental disorders. It is characterized by attention difficulty, hyperactivity, and impulsiveness. 

What is Amphetamine?

Amphetamine is a potent drug in ADHD therapy because it includes d-amphetamine and l-amphetamine salts that are combined in the ratio of 3:1, respectively. The drug is best suited for children above the age of three. It also includes various binders, guaranteeing that the body can function properly. 

Amphetamine is available as a tablet or capsule. The medication triggers the production of more dopamine and norepinephrine, thus exciting the nerve cells, making the individual feel more at ease, and assisting in alleviating their anxiety. 

The mental effects of amphetamine use can be compared to the high that is gotten from the intake of cocaine, except that the effects of cocaine only last around one hour. In contrast, the effects of amphetamine consumption might last from a few minutes to many hours. Using other drugs or alcohol together with amphetamine may intensify the euphoria, but you may be endangering your life.

What is Dextroamphetamine?

Dextroamphetamine is mainly composed of d-amphetamine, a less powerful but effective version of amphetamine. While both amphetamine and dextroamphetamine therapies accomplish the same results, removing one of the salts makes dextroamphetamine less damaging to patients. Although youngsters account for most instances of ADHD, anyone over three can take the drug, according to a doctor’s prescription.

There are two capsule options for dextroamphetamine: the extended capsule, which is taken entirely at once, and the span capsule, which is taken gradually over a longer period. It is important to ensure you take this medication under the supervision and prescription of a professional healthcare practitioner because it has a broad spectrum of physiological and psychological side effects.

Uses of Amphetamines and Dextroamphetamine

Dextroamphetamine and amphetamine work by altering the levels of certain endogenous brain neurotransmitters. This drug combination has shown potential in the treatment of ADHD. It might help you concentrate better, pay attention for longer periods, and control behavioral disorders. They may also be used to improve attentiveness and boost listening skills.

How Should Amphetamines and Dextroamphetamine Be Used?

The tablet may be taken with or without meals, but it must be taken consistently as prescribed. Dextroamphetamine and amphetamine shouldn’t be taken late in the afternoon or evening since they can prevent you from falling asleep. Always follow the prescription on your medication’s label, and if you have any questions, speak to your doctor or pharmacist.

The extended-release capsules should be consumed whole without being chewed or broken. If an extended-release capsule cannot be taken whole, the contents may be sprinkled over a spoonful of applesauce. Only split the capsule open if you are having problems taking it whole. Fill your mouth with the applesauce mixture and swallow it whole without chewing. You should not save the medicine-in-applesauce combination for subsequent use, and you should not split the contents of a capsule into more than one dose.

Because dexamphetamine and amphetamine are stimulants, your doctor will most likely begin with a modest dosage and progressively increase it, but no more than once per week. Your doctor may advise you to stop dextroamphetamine or amphetamine to determine if you still need the medicines. Because of the various ways the body processes the chemical inside each product, switching between different dextroamphetamine and amphetamine preparations is not encouraged.

Difference Between Amphetamine and Dextroamphetamine

While amphetamine and dextroamphetamine are very similar, there are a couple of differences between the two drugs. While dextroamphetamine can only be obtained as a capsule, amphetamine is available as a tablet and an extended-release capsule. 

Also, the use of amphetamine triggers the release of dopamine and norepinephrine. On the other hand, dextroamphetamine triggers the release of only dopamine. 

Furthermore, dextroamphetamine comprises only d-amphetamine, while amphetamine is obtained by mixing d-amphetamine and l-amphetamine at a recommended ratio of 3:1.

Side Effects of Amphetamine and Dextroamphetamine

The major side effects of amphetamine and dextroamphetamine include:

  • nervousness
  • headache
  • changes in sex drive or ability
  • painful menstrual cramps
  • dry mouth
  • constipation
  • diarrhea
  • nausea
  • weight loss

Possible Risk Of Drug Abuse And Addiction

The effects of dextroamphetamine and amphetamine may be very addictive when combined. Inform your primary care physician about any previous issues with alcohol or drug abuse. Do not raise your dosage, administration frequency, or therapy duration without first seeing your doctor. Taking too much of the stimulants dextroamphetamine and amphetamine may result in addiction and possibly bizarre behavior.

Those who have taken too much dextroamphetamine or amphetamine should see a doctor before discontinuing therapy. Your doctor will most likely gradually reduce your dosage while closely monitoring you. Sudden withdrawal from stimulants such as dextroamphetamine and amphetamine may induce intense depression and fatigue.

Another way to reduce the likelihood of addiction is to avoid giving your prescription to someone else without first consulting your doctor or pharmacist. Because dextroamphetamine and amphetamine are highly addictive, doing so may put the person at risk of developing a drug addiction.

Amphetamines and dextroamphetamines are regulated drugs due to the potential for damage to people who use them. Therefore, you are always advised to lock up the amphetamine and dextroamphetamine so that no one else comes across them accidentally or on purpose. Keep note of how many pills or capsules are in the container to check whether any are missing.


Dextroamphetamine is an amphetamine enantiomer. It acts as a stimulant on the central nervous system (CNS) and is often used to treat narcolepsy and attention deficit hyperactivity disorder (ADHD).

The two amphetamine isomers that have an impact on the body are dextroamphetamine (also known as d-amphetamine) and levoamphetamine (also known as l-amphetamine). Dextroamphetamine is three to five times stronger than levoamphetamine.

Attention deficit hyperactivity disorder (ADHD) is treated with a combination of dextroamphetamine and amphetamine sold under the brand names Adderall, Adderall XR, and Mydayis.

It works by altering the levels of certain endogenous brain neurotransmitters. Both amphetamine and dextroamphetamine belong to the stimulant family of medications. It may help you concentrate more efficiently, boost self-control, and improve your attention.

Get Help Today

ADHD drugs have a significant potential for abuse due to their intoxicating effects. Therefore, you must get professional assistance if you or a loved one abuses prescription stimulant medications. Abuse of these medications may lead to major problems, including fatal overdoses, but therapy can help you overcome your addiction and resume a healthy, productive life.

People must constantly remember that asking for help does not have to make them feel humiliated. Giving medical practitioners the necessary information allows them to work with patients to develop the most successful treatment approach for their specific circumstances. Testing may not easily detect drug misuse or addiction, but a medical specialist may speak to a patient about their substance usage and identify any risk factors that might suggest it.

At New Hope Healthcare, we understand the possible consequences of addiction. As a result, our comprehensive approach to treating addiction may benefit those struggling with drug addiction. Contact us today at 865-800-0947

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