substance abuse13 min readJune 9, 2025

Commonly Abused OTC Drugs: Warning Signs and Health Risks

Robin Campbell, LMFT, PHD Commonly Abused OTC Drugs: Warning Signs and Health Risks Over-the-counter (OTC) medicine is often seen as.

Maverick

Clinical Editorial Team

    Commonly Abused OTC Drugs: Warning Signs and Health Risks

    Over-the-counter (OTC) medicine is often seen as a safer alternative to prescription medications, but misuse is a growing concern. Many people—especially teens—turn to cold medications, sleep aids, and allergy medications for their active ingredients, which are the specific chemicals in the medication responsible for its effects and potential for misuse. In large doses, these active ingredients can produce mild stimulation, hallucinations, or sedation. OTC medication abuse, such as abuse dxm (dextromethorphan abuse) found in many cough syrups and commonly misused by youths, can activate opioid receptors and mimic the effects of street drugs or even some illegal drugs. The risks and potential for abuse of over the counter medication highlight the importance of recognizing misuse and seeking appropriate help.

    OTC drug abuse is sometimes used for weight control, self-treatment of severe pain, or as a substitute when other substances aren’t available. People may not realize that using excessive amounts or combining OTC drugs with other medications can cause irregular heartbeat, brain damage, or serious drug interactions. The Drug Enforcement Administration and healthcare professionals warn that what starts in medicine cabinets can quickly lead to drug addiction and the need for long-term chronic pain management or entry into the recovery process.

    Understanding OTC Drugs

    Over-the-counter (OTC) drugs are medications sold without a prescription and commonly used for pain relief, cold symptoms, allergies, and digestive issues. They are safe when taken as directed, but problems arise when people take more than recommended or use them to feel high. Certain OTC drugs, like cough suppressants with DXM or antihistamines like diphenhydramine, are frequently misused for their psychoactive effects.

    Commonly Abused OTC Drugs

    Some over-the-counter drugs are misused for their mood-altering or physical effects. While easily accessible, these drugs can cause serious health problems when taken in high doses or for non-medical reasons.

    • Dextromethorphan (DXM): Found in cough syrups; misused for euphoria and hallucinations
    • Diphenhydramine: Found in antihistamines like Benadryl; abused for sedation and delirium
    • Pseudoephedrine: Found in cold medicines; misused as a stimulant or for meth production
    • Laxatives: Abused to control weight or induce rapid bowel movements
    • Diuretics: Misused to shed water weight, often linked to eating disorders
    • Acetaminophen: Overused for pain relief; can lead to liver damage
    • Ibuprofen: Excessive use can cause stomach bleeding or kidney problems

    Signs and Symptoms of OTC Drug Abuse

    OTC drug abuse often shows up through changes in behavior, mood, and physical health. These signs may start subtly but grow more noticeable as misuse increases.

    • Physical signs: Drowsiness, dizziness, nausea, slurred speech, or poor coordination
    • Behavioral signs: Secrecy, frequent OTC purchases, avoiding responsibilities
    • Mental changes: Confusion, mood swings, anxiety, or hallucinations
    • Health problems: Stomach pain, liver issues, or increased heart rate
    • Appearance changes: Weight loss, fatigue, or neglect of hygiene

    What Causes OTC Drug Abuse?

    OTC drug abuse is often driven by easy access and the false belief that these medications are always safe. In many countries, the easy availability of OTC drugs contributes to their misuse. Many people think using more than the label says will give faster or stronger relief. Some misuse OTC drugs to feel high, self-medicate stress, or manage anxiety without help.

    Teens and young adults may abuse these drugs out of curiosity, peer pressure, or for escape. Adults may turn to them due to untreated pain, sleep problems, or mental health issues. Without proper support, repeated misuse can quickly lead to dependence or serious health risks.

    Can You Get Addicted to OTC Medications?

    Yes, some OTC medications can lead to addiction when misused over time. Repeated high doses can cause physical dependence, where the body needs the drug to feel normal. Psychological addiction can also develop, especially when used to escape stress or emotional pain.

    Drugs like DXM, diphenhydramine, and pseudoephedrine carry higher addiction risks. Users may build tolerance, needing more for the same effect, which increases health dangers. Treatment is often needed to safely stop use and address underlying issues.

    Prevalence of OTC Drug Abuse

    OTC drug abuse is rising, especially among teens and young adults. Surveys show many start with common cold or allergy medicines due to their easy availability. DXM-containing cough syrups are among the most frequently misused.

    The National Institute on Drug Abuse reports that misuse often begins in high school. Many users falsely believe OTC drugs are safer than prescriptions. This misunderstanding fuels continued misuse and increases the risk of long-term harm.

    School Strategies to Prevent OTC Drug Abuse

    Schools play a key role in stopping OTC drug abuse early. Education programs can teach students the risks of misuse and the importance of reading drug labels. Health classes should cover real examples and facts about addiction.

    Staff training helps teachers recognize signs of drug abuse and respond quickly. Schools can also set strict rules for OTC medications on campus. Partnering with parents and local treatment centers strengthens prevention efforts.

    When OTC Use Turns Into a Bigger Problem

    OTC use becomes a problem when it’s no longer for relief but used to feel high or cope with stress. This shift often includes higher doses, frequent use, or secretive behavior. These patterns can signal growing dependence or addiction.

    Physical damage like liver or heart issues may appear, along with mental changes like mood swings or confusion. When daily life, work, or relationships suffer, professional help is often needed to regain control.

    Comparing OTC Drug Abuse and Prescription Drug Abuse

    OTC and prescription drug abuse both involve using medications in ways not intended. The key difference lies in access—OTC drugs are available without a prescription, making them easier to obtain. Prescription drugs, while more controlled, are often stronger and carry higher overdose risks.

    Both forms of abuse can lead to dependence, health damage, and addiction. OTC abuse is often underestimated due to the drugs’ legal status, while prescription abuse tends to involve opioids, stimulants, or sedatives. Both require serious attention and treatment to prevent long-term harm.

    Legal Consequences of Misusing OTC Drugs

    • Possession with Intent to Misuse: Having large quantities can raise suspicion of abuse or illegal distribution
    • School or Workplace Discipline: Misuse on campus or job sites may lead to suspension, expulsion, or termination
    • Driving Under the Influence (DUI): Operating a vehicle while impaired by OTC drugs can result in DUI charges
    • Theft or Fraud: Stealing medications or altering purchase limits may lead to criminal charges
    • Supplying to Minors: Giving or selling OTC drugs to others, especially minors, can result in legal action
    • Tampering Charges: Modifying packaging or drug contents may lead to tampering or drug-related offenses

    Legal requirements also regulate the sale and purchase of certain over-the-counter drugs, such as pseudoephedrine. Laws like the Combat Methamphetamine Epidemic Act of 2005 set strict limits on how much can be bought and require pharmacies to track sales. These legal frameworks are designed to monitor and prevent OTC medication abuse, and there is ongoing discussion about updating regulations to address new challenges in misuse and distribution.

    Effects and Risks of OTC Drug Abuse

    Short-Term Effects:

    • Drowsiness, dizziness, or confusion
    • Nausea, vomiting, or stomach pain
    • Fast heart rate or high blood pressure
    • Poor coordination or impaired judgment

    Long-Term Risks:

    • Liver or kidney damage
    • Memory problems and cognitive decline
    • Physical dependence or addiction

    Recognizing Teen Abuse of OTC Medications

    Teens may misuse OTC drugs for quick highs or to cope with stress. Signs include sudden mood changes, drowsiness, or loss of interest in usual activities. You may notice empty medicine packages, secretive behavior, or slipping grades.

    Physical symptoms like red eyes, poor coordination, or nausea can also appear. Frequent trips to the store for cough syrup or allergy meds may signal a problem. Early recognition helps prevent deeper health and behavioral issues.

    How to Store OTC Drugs to Prevent Misuse

    Keep OTC medications in a locked cabinet or a place out of sight and reach, especially from teens and children. Avoid storing them in common areas like bathrooms or kitchens. Limit how much you keep at home to reduce temptation.

    Track expiration dates and monitor how much is used. Dispose of unused or expired medications through take-back programs or according to FDA guidelines. Clear storage rules help reduce the chance of accidental or intentional misuse.

    Mental Health Effects of OTC Drug Misuse

    OTC drug misuse can lead to a range of mental health problems, especially when used frequently or in high doses. These effects may start mild but grow worse over time, affecting mood, thinking, and behavior.

    Common mental health issues linked to misuse include:

    • Anxiety: Nervousness, panic attacks, or constant worry
    • Depression: Sadness, low energy, or loss of interest in daily life
    • Paranoia: Irrational fear, suspicion, or distrust of others
    • Hallucinations: Seeing or hearing things that aren’t real
    • Memory problems: Difficulty focusing or recalling information
    • Mood swings: Sudden changes in emotion or irritability
    • Insomnia: Trouble falling or staying asleep
    • Emotional numbness: Feeling disconnected or flat

    If left untreated, these issues can lead to long-term psychological harm and increase the risk of addiction.

    Myths About OTC Drug Safety

    Many people assume OTC drugs are always safe because they don’t need a prescription. This belief often leads to misuse and serious health risks. Understanding the truth helps prevent harm and addiction.

    Common myths include:

    • “OTC drugs can’t be addictive.”Some OTC drugs, like DXM or diphenhydramine, can lead to dependence with repeated misuse.
    • “If it’s sold in stores, it’s harmless.”OTC drugs can cause liver damage, heart problems, or overdose when taken in large amounts.
    • “More equals faster relief.”Taking extra doses doesn’t speed recovery—it increases the risk of side effects and long-term damage.
    • “It’s safer than street or prescription drugs.”OTC misuse can cause severe mental and physical health problems, just like other forms of drug abuse.

    The Role of Pharmacies in Preventing OTC Abuse

    Pharmacies serve as a frontline defense against OTC drug misuse. Pharmacists can educate customers on proper use, side effects, and safe dosing. They can also spot unusual purchasing patterns or frequent high-quantity buys.

    Some pharmacies limit sales of high-risk OTC drugs like pseudoephedrine or require ID for purchase. Clear labeling, locked displays, and printed warnings help reduce misuse. By staying alert and informed, pharmacists help protect individuals and communities from OTC abuse.

    OTC Drug Withdrawal Symptoms

    Stopping OTC drug misuse after frequent or high-dose use can lead to withdrawal. Symptoms vary based on the drug and length of use, but they often affect both body and mind. These effects may begin within hours or days after the last dose.

    Common withdrawal symptoms include:

    • Physical: Headaches, sweating, shaking, nausea, muscle aches
    • Mental: Anxiety, irritability, depression, restlessness
    • Sleep issues: Insomnia or vivid nightmares
    • Cravings: Strong urge to use the drug again

    Severe symptoms may require medical support to manage safely and reduce relapse risk.

    How to Support a Loved One Abusing OTC Drugs

    Support starts with observation and open, non-judgmental conversation. Look for signs like mood changes, secrecy, or frequent OTC purchases. Gently express concern and share what you’ve noticed without blame.

    Encourage them to talk about what they’re feeling or why they’re using the drug. Offer help finding a doctor, counselor, or treatment program. Stay patient and consistent—recovery often takes time, trust, and steady support.

    Addiction Treatment Options

    Common treatment options include:

    • Residential treatment: 24/7 care in a structured setting
    • Behavioral therapy: Teaches coping skills and addresses triggers
    • Group counseling: Offers peer support and shared experiences
    • Family therapy: Involves loved ones to strengthen recovery

    Treatment should also address any mental health conditions tied to the drug use. Recovery works best with ongoing support and follow-up care.

    Does Insurance Cover OTC Drug Abuse Treatment?

    Yes, many insurance plans do cover treatment for OTC drug abuse. Coverage often includes services like detox, therapy, outpatient care, or residential programs. The exact benefits depend on the provider, plan type, and medical necessity.

    Most insurers require a formal diagnosis and treatment plan from a licensed provider. Patients may need pre-authorization or referrals to begin care. It’s important to contact the insurance company directly to confirm specific coverage details.

    Conclusion

    OTC medicine misuse is not harmless—prolonged use, large doses, or mixing with other substances can carry dangerous and even life-threatening consequences. Abuse of pain relievers, sleep aids, and cold medications—especially those containing dextromethorphan or ingredients that activate opioid receptors—is now considered abuse by medical experts and the Drug Enforcement Administration alike. Most patients who seek help report starting with over the counter medicines, unaware of their addictive properties and adverse effects.

    If someone is misusing OTC medications or struggling with drug addiction, reaching out to a healthcare professional is a critical first step. Early action can prevent serious damage from drug interactions or dependency and support a safer, more informed recovery process.

    Seeking Treatment? We Can Help!

    At New Hope Healthcare, as an in-network provider we work with most insurance plans, such as:

    • First Health Network
    • Aetna
    • Humana
    • TriWest VA
    • UMR
    • Oscar
    • Celtic Insurance
    • And More

    If you or a loved one are struggling with mental health challenges or substance abuse, seeking treatment and emotional support is crucial. Consulting a doctor can provide the necessary support and guidance for your teen. Reach out to New Hope Healthcare today. Our team of compassionate professionals is here to support your journey towards lasting well-being. Effective medication management is a crucial part of the treatment process to ensure safety and success. Give us a call at 866-799-0806.

    Visit SAMHSA for more information.

    Commonly Abused OTC Drugs

    Frequently Asked Questions

    What are the most commonly abused OTC drugs?

    Cough medicines with dextromethorphan (DXM), antihistamines like diphenhydramine, and cold medicines with pseudoephedrine are the most frequently misused.

    Why do people abuse over-the-counter medications?

    People misuse OTC drugs to feel high, self-medicate for pain or anxiety, or try to lose weight. Many think these drugs are safer because they’re easy to buy.

    Can OTC drug abuse lead to addiction or serious health problems?

    Yes. Long-term misuse can cause liver damage, heart issues, and mental health problems. Abuse can also lead to physical dependence or addiction.

    People Also Asked

    Can you get high from over-the-counter drugs?

    Yes, some OTC drugs like cough syrup with DXM or antihistamines can cause a high when taken in large amounts. This misuse is dangerous and can harm the brain.

    What are the dangers of abusing OTC medications?

    OTC drug abuse can cause heart problems, liver damage, seizures, and mental confusion. It may also lead to addiction or fatal overdose in severe cases.

    How can I tell if someone is abusing OTC drugs?

    Watch for empty medicine packages, mood changes, drowsiness, or confusion. Secretive behavior and frequent OTC purchases may also be warning signs.

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